GLP1R_GIPR_pocket_matrix

GLP1R_GIPR_pocket_matrix packed 2026-08-23

2 Proteins

3 Co-folded partners

3 Ligands

2 Pockets

2 Apo structure references

20 Predictions

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Campaign summary

Field	Value	Details
Input file	boltz_input.md	boltz_input.md
Proteins	2	4 protein block(s) in 2 group(s): GLP1R (463 aa); GIPR (466 aa); GLPAP (463 aa); GIPAP (466 aa)
Co-folded partners	3	GNAS (protein, 394 aa); GNB1 (protein, 340 aa); GNG2 (protein, 71 aa)
Ligands	3	ORFO (SMILES); LSN1 (SMILES); LSN2 (SMILES)
Pockets	2	41Y, V6G
Apo structure references	2	GLPAP, GIPAP
Predictions	20	GLP1R_ORFO, GLP1R_ORFO_41Y, GLP1R_ORFO_V6G, GLP1R_LSN1, GLP1R_LSN1_41Y, GLP1R_LSN1_V6G, GLP1R_LSN2, GLP1R_LSN2_41Y, GLP1R_LSN2_V6G, GIPR_ORFO, GIPR_ORFO_41Y, GIPR_ORFO_V6G, GIPR_LSN1, GIPR_LSN1_41Y, GIPR_LSN1_V6G, GIPR_LSN2, GIPR_LSN2_41Y, GIPR_LSN2_V6G, GLPAP, GIPAP
Predict affinity	yes	pIC50 predicted for every ligand-bound prediction
Ligand chemistry	2 of 3 flagged	LSN1, LSN2 -- see "Ligand preparation" below
Boltz predict runtime	20h 17m 13s	across 51 run invocations
Accelerator	gpu	gpu = Metal/CUDA backend used; cpu = no GPU available
Workers	2	parallel data-loading workers (Boltz's own default is 2)
MPS watermark	1.0	PYTORCH_MPS_HIGH_WATERMARK_RATIO cap -- lower avoids swap on Apple unified memory
Max parallel samples	1	Boltz's own --max_parallel_samples
Max MSA sequences	4096	cap on MSA sequences used for co-evolution features

Reference structures

The experimental structures this campaign was built on: where each pocket came from, and what the secondary-structure comparison measures against.

Pocket definitions

Pocket	From	Proteins	Contacts
41Y	7RBT	GIPR, GLP1R	74
V6G	7E14	GIPR, GLP1R	121

Secondary-structure references

Protein	Structure	State	Contents	Chain
GLP1R	5vew.cif	no G protein bound	2 chain(s), bound: 97Y	A
GIPR	8wa3.cif	active (G protein bound)	5 chain(s), bound: none	auto

State is read from the file, not from its title. A structure titled “apo” is often ligand-free and G-protein-coupled, which is the active state.

Ligand definitions

Ligand	Class	Given as	Experimental structure
ORFO	Control	SMILES	V6G
LSN1	Control	SMILES	41Y
LSN2	Control	SMILES	none

A control has been verified experimentally, by structure or by assay, so its prediction can be checked; an experimental compound is under investigation, with nothing to check against. Experimental compounds are ringed in red in the charts.

pIC50 vs confidence score

Click a point to open that target, in the panel below the Targets table.

pIC50 vs binder probability

Click a point to open that target, in the panel below the Targets table.

Ranked predicted pIC50

Click a point to open that target, in the panel below the Targets table.

Ranked confidence

Click a point to open that target, in the panel below the Targets table.

Summary table

Identity							Affinity		▸ Confidence (6)	▸ Interactions (7)	Structure
Run	Protein	Partner	Ligand	Pocket	Class	Summary	Binder	pIC50	Score	pTM	ipTM	Lig	PPI	pLDDT	Total	Phob	H	π	Hal	π-cation	Salt	CIF
11	GIPR	GNAS, GNB1, GNG2	ORFO	41Y	Control		0.27	11.38	0.84	0.88	0.90	0.97	0.89	0.82	11.00	11	0	0	0	0	0	CIF
2	GLP1R	GNAS, GNB1, GNG2	ORFO	41Y	Control		0.58	11.18	0.83	0.88	0.88	0.97	0.88	0.82	7.00	7	0	0	0	0	0	CIF
12	GIPR	GNAS, GNB1, GNG2	ORFO	V6G	Control		0.45	10.47	0.83	0.87	0.87	0.91	0.87	0.82	13.00	10	2	0	0	1	0	CIF
3	GLP1R	GNAS, GNB1, GNG2	ORFO	V6G	Control		0.55	10.24	0.83	0.87	0.87	0.96	0.86	0.82	14.00	10	3	1	0	0	0	CIF
10	GIPR	GNAS, GNB1, GNG2	ORFO	Unc	Control		0.32	9.54	0.79	0.79	0.76	0.82	0.76	0.79	13.00	12	0	1	0	0	0	CIF
5	GLP1R	GNAS, GNB1, GNG2	LSN1	41Y	Control		0.89	9.48	0.84	0.92	0.92	0.99	0.91	0.82	13.00	11	1	1	0	0	0	CIF
1	GLP1R	GNAS, GNB1, GNG2	ORFO	Unc	Control		0.49	9.19	0.76	0.80	0.75	0.80	0.75	0.77	14.00	12	2	0	0	0	0	CIF
14	GIPR	GNAS, GNB1, GNG2	LSN1	41Y	Control		0.74	8.85	0.85	0.89	0.90	0.98	0.90	0.84	11.00	9	1	1	0	0	0	CIF
8	GLP1R	GNAS, GNB1, GNG2	LSN2	41Y	Control		0.65	8.72	0.85	0.91	0.91	0.99	0.91	0.83	9.00	7	1	1	0	0	0	CIF
18	GIPR	GNAS, GNB1, GNG2	LSN2	V6G	Control		0.53	8.57	0.82	0.86	0.87	0.88	0.87	0.81	12.00	6	5	0	0	0	1	CIF
9	GLP1R	GNAS, GNB1, GNG2	LSN2	V6G	Control		0.60	8.40	0.83	0.89	0.88	0.95	0.88	0.82	12.00	9	1	1	0	1	0	CIF
17	GIPR	GNAS, GNB1, GNG2	LSN2	41Y	Control		0.70	8.40	0.84	0.87	0.88	0.99	0.88	0.83	11.00	9	1	1	0	0	0	CIF
15	GIPR	GNAS, GNB1, GNG2	LSN1	V6G	Control		0.54	8.35	0.83	0.87	0.88	0.92	0.88	0.82	11.00	8	2	0	0	0	1	CIF
6	GLP1R	GNAS, GNB1, GNG2	LSN1	V6G	Control		0.60	8.26	0.84	0.89	0.88	0.95	0.88	0.83	18.00	13	3	2	0	0	0	CIF
13	GIPR	GNAS, GNB1, GNG2	LSN1	Unc	Control		0.28	8.12	0.77	0.75	0.70	0.61	0.71	0.78	17.00	15	2	0	0	0	0	CIF
4	GLP1R	GNAS, GNB1, GNG2	LSN1	Unc	Control		0.47	7.84	0.77	0.77	0.73	0.68	0.73	0.78	16.00	12	3	0	1	0	0	CIF
16	GIPR	GNAS, GNB1, GNG2	LSN2	Unc	Control		0.49	7.70	0.73	0.73	0.69	0.44	0.70	0.75	22.00	18	4	0	0	0	0	CIF
7	GLP1R	GNAS, GNB1, GNG2	LSN2	Unc	Control		0.56	7.70	0.75	0.76	0.71	0.68	0.72	0.76	7.00	6	0	0	0	1	0	CIF
19	GLPAP	GNAS, GNB1, GNG2	Apo	N/A	N/A	N/A	N/A	N/A	0.82	0.86	N/A	N/A	N/A	0.81	N/A	N/A	N/A	N/A	N/A	N/A	N/A	CIF
20	GIPAP	GNAS, GNB1, GNG2	Apo	N/A	N/A	N/A	N/A	N/A	0.83	0.86	N/A	N/A	N/A	0.82	N/A	N/A	N/A	N/A	N/A	N/A	N/A	CIF

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🎯 affinity Likely binder (p ≥ 0.7) Uncertain (0.3-0.7) Likely non-binder (p < 0.3)

🛡️ confidence High confidence (≥ 0.7) Moderate confidence (0.5-0.7) Low confidence (< 0.5)

Predictions

One row per prediction. Click one to see its pose and interactions, in the panel below.

Flagged only

Run	Prediction	Protein	Ligand	Pocket	Class	Confidence	pIC50	Interactions	Flags

Target

Overall structure

Interaction diagram

Detected interactions

Metrics

Ligand pose

Superposed targets

Sequence

Pockets

2 named pocket(s) (41Y, V6G) plus an unconstrained baseline; contacts are enforced within 4 A.

Pocket	Protein	Ligands	Runs	Targets	Contacts
41Y	GIPR	ORFO, LSN1, LSN2	11, 14, 17	3	37 residue(s)
41Y	GLP1R	ORFO, LSN1, LSN2	2, 5, 8	3	37 residue(s)
V6G	GIPR	ORFO, LSN1, LSN2	12, 15, 18	3	59 residue(s)
V6G	GLP1R	ORFO, LSN1, LSN2	3, 6, 9	3	62 residue(s)
Unconstrained	GIPR	ORFO, LSN1, LSN2	10, 13, 16	3	none -- ligand placed freely
Unconstrained	GLP1R	ORFO, LSN1, LSN2	1, 4, 7	3	none -- ligand placed freely

Where the ligands landed

Ligand preparation

2 of 3 ligand(s) flagged for chemistry review -- these are advisory, not errors; verify the input SMILES reflects what you intended before trusting the results below.

Ligand	Chemistry notes
LSN1	ionizable group(s) present (primary/secondary amine, phenol) -- verify the SMILES reflects your intended protonation state
LSN2	ionizable group(s) present (phenol) -- verify the SMILES reflects your intended protonation state

Ligand structures

shared scaffold -- 2/3 ligandsSundefined stereocentreAcarboxylic acidNprimary/secondary aminePhphenolSO3sulfonic acidsaltsalt/disconnected fragment

ORFO

MW 883 · cLogP 7.4 · TPSA 156

LSN1NPh

MW 505 · cLogP 8.1 · TPSA 45

LSN2Ph

MW 462 · cLogP 5.8 · TPSA 62

Download PDF · Download SMILES

Scaffolds: Bemis-Murcko, exact match first, then Tanimoto-clustered (Morgan r=2, 2048-bit, threshold 0.60) whole-group MCS as a verified fallback. Minimum highlighted substructure size: 8 heavy atoms. Stereocentre/ionizable-group highlighting from this campaign's own ligand-preparation check (see above).

Interaction counts by type

Click a point to open that target, in the panel below the Targets table.

SSE motif shifts (apo vs holo)

Identity						Shift			Helix geometry				Boundary		Backbone
Family	Target	Ligand	Motif	Kind	Source	N res	RMSD (A)	Centroid delta (A)	Axis rot (deg)	Kink apo (deg)	Kink holo (deg)	Kink delta (deg)	Start delta	End delta	Flagged phi/psi
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	H8	helix	gpcr	17	1.20	0.64	6.17	13.34	11.05	-2.29	1.00	2.00	0
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	H8	helix	gpcr	17	1.12	0.87	4.03	13.34	9.39	-3.96	1.00	2.00	0
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	H8	helix	gpcr	17	1.18	0.91	4.21	13.34	9.13	-4.21	1.00	7.00	0
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	H8	helix	gpcr	20	2.04	1.69	5.93	5.05	11.74	6.69	142.00	150.00	3
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	H8	helix	gpcr	20	2.06	1.67	6.18	5.05	12.27	7.22	142.00	149.00	3
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	H8	helix	gpcr	20	1.73	1.50	2.95	5.05	8.78	3.74	142.00	149.00	3
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	TM1	helix	gpcr	32	1.08	0.76	1.24	3.49	10.54	7.05	N/A	N/A	0
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	TM1	helix	gpcr	32	1.75	1.21	4.77	3.49	7.96	4.47	N/A	N/A	0
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	TM1	helix	gpcr	32	1.34	1.01	2.98	3.49	6.12	2.63	N/A	N/A	1
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	TM1	helix	gpcr	35	3.15	1.99	7.85	8.70	16.12	7.42	N/A	N/A	2
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	TM1	helix	gpcr	35	3.69	2.13	9.85	8.70	15.54	6.84	N/A	N/A	2
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	TM1	helix	gpcr	35	4.60	2.60	11.82	8.70	23.20	14.50	N/A	N/A	2
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	TM2	helix	gpcr	28	2.24	0.68	3.58	17.56	6.33	-11.23	N/A	N/A	4
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	TM2	helix	gpcr	28	1.30	0.56	3.02	17.56	15.36	-2.20	N/A	N/A	2
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	TM2	helix	gpcr	28	1.80	0.80	5.31	17.56	12.38	-5.19	N/A	N/A	2
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	TM2	helix	gpcr	28	0.93	0.59	2.07	4.18	12.85	8.68	N/A	N/A	1
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	TM2	helix	gpcr	28	0.88	0.64	1.23	4.18	10.38	6.20	N/A	N/A	0
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	TM2	helix	gpcr	28	0.99	0.79	0.37	4.18	12.14	7.96	N/A	N/A	0
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	TM3	helix	gpcr	32	1.19	0.70	2.42	15.22	17.44	2.22	N/A	N/A	2
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	TM3	helix	gpcr	32	1.30	0.91	1.65	15.22	17.50	2.28	N/A	N/A	2
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	TM3	helix	gpcr	32	1.30	0.91	1.85	15.22	16.20	0.98	N/A	N/A	3
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	TM3	helix	gpcr	37	1.08	0.49	2.57	16.75	17.04	0.29	N/A	N/A	1
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	TM3	helix	gpcr	37	0.93	0.72	0.58	16.75	14.80	-1.95	N/A	N/A	0
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	TM3	helix	gpcr	37	1.11	0.85	1.80	16.75	14.58	-2.17	N/A	N/A	0
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	TM4	helix	gpcr	29	0.76	0.23	2.21	10.55	7.01	-3.54	-11.00	-2.00	2
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	TM4	helix	gpcr	29	0.91	0.35	2.33	10.55	8.39	-2.16	-12.00	-2.00	2
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	TM4	helix	gpcr	29	1.14	0.55	3.08	10.55	8.57	-1.98	-12.00	-2.00	4
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	TM4	helix	gpcr	27	1.14	0.95	0.76	4.63	7.06	2.43	125.00	119.00	3
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	TM4	helix	gpcr	27	1.38	1.20	1.25	4.63	3.79	-0.83	124.00	120.00	3
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	TM4	helix	gpcr	27	1.71	1.51	2.45	4.63	3.33	-1.29	124.00	120.00	3
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	TM5	helix	gpcr	35	2.17	0.72	2.24	7.73	20.05	12.32	1.00	0.00	7
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	TM5	helix	gpcr	35	2.58	1.33	3.90	7.73	18.63	10.90	1.00	0.00	7
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	TM5	helix	gpcr	35	2.61	1.26	4.63	7.73	18.98	11.26	1.00	0.00	7
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	TM5	helix	gpcr	35	1.24	1.02	1.20	18.00	16.71	-1.30	126.00	134.00	1
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	TM5	helix	gpcr	35	1.20	0.85	2.15	18.00	14.72	-3.29	126.00	134.00	0
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	TM5	helix	gpcr	35	1.32	0.88	2.78	18.00	14.58	-3.42	126.00	133.00	1
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	TM6	helix	gpcr	28	9.36	5.68	24.93	19.85	74.11	54.26	-2.00	-7.00	6
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	TM6	helix	gpcr	28	8.86	5.10	24.15	19.85	67.42	47.57	-2.00	-7.00	6
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	TM6	helix	gpcr	28	9.17	5.51	22.90	19.85	75.44	55.59	-2.00	-7.00	8
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	TM6	helix	gpcr	29	7.53	4.46	16.64	30.74	67.89	37.15	121.00	103.00	8
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	TM6	helix	gpcr	29	7.26	4.54	13.74	30.74	69.12	38.37	121.00	103.00	9
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	TM6	helix	gpcr	29	7.52	4.99	13.80	30.74	64.94	34.19	121.00	103.00	9
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	TM7	helix	gpcr	26	6.37	3.41	22.20	40.80	34.73	-6.08	-10.00	-13.00	4
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	TM7	helix	gpcr	26	2.92	1.95	6.73	40.80	35.00	-5.80	-9.00	1.00	3
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	TM7	helix	gpcr	26	6.82	3.76	23.99	40.80	27.78	-13.03	-6.00	-13.00	4
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	TM7	helix	gpcr	29	3.42	1.95	12.67	35.94	33.84	-2.10	157.00	147.00	5
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	TM7	helix	gpcr	29	2.81	1.33	10.61	35.94	24.62	-11.32	157.00	147.00	5
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	TM7	helix	gpcr	29	3.82	2.06	13.86	35.94	20.71	-15.23	157.00	147.00	5
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	ECL2	loop	gpcr	3	1.07	0.82	N/A	N/A	N/A	N/A	N/A	N/A	0
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	ECL2	loop	gpcr	3	1.09	0.94	N/A	N/A	N/A	N/A	N/A	N/A	0
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	ECL2	loop	gpcr	3	1.30	1.11	N/A	N/A	N/A	N/A	N/A	N/A	1
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	ECL2	loop	gpcr	3	2.76	1.94	N/A	N/A	N/A	N/A	N/A	N/A	3
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	ECL2	loop	gpcr	3	2.39	1.17	N/A	N/A	N/A	N/A	N/A	N/A	3
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	ECL2	loop	gpcr	3	2.47	1.59	N/A	N/A	N/A	N/A	N/A	N/A	3
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	ICL1	loop	gpcr	4	0.45	0.43	N/A	N/A	N/A	N/A	N/A	N/A	0
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	ICL1	loop	gpcr	4	0.74	0.70	N/A	N/A	N/A	N/A	N/A	N/A	0
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN1	LSN1	ICL1	loop	gpcr	4	0.81	0.78	N/A	N/A	N/A	N/A	N/A	N/A	0
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	ICL1	loop	gpcr	4	1.06	0.85	N/A	N/A	N/A	N/A	N/A	N/A	4
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	ICL1	loop	gpcr	4	1.40	1.18	N/A	N/A	N/A	N/A	N/A	N/A	4
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN1	LSN1	ICL1	loop	gpcr	4	1.06	0.80	N/A	N/A	N/A	N/A	N/A	N/A	4
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	H8	helix	gpcr	17	14.97	9.40	101.88	13.34	26.53	13.18	1.00	9.00	0
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	H8	helix	gpcr	17	1.23	1.10	2.38	13.34	11.36	-1.98	1.00	11.00	0
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	H8	helix	gpcr	17	1.01	0.76	3.74	13.34	11.38	-1.96	1.00	7.00	0
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	H8	helix	gpcr	20	9.45	3.40	6.16	5.05	133.90	128.85	142.00	142.00	7
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	H8	helix	gpcr	20	2.35	1.88	7.51	5.05	9.89	4.84	142.00	150.00	3
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	H8	helix	gpcr	20	1.94	1.63	4.27	5.05	13.19	8.14	142.00	149.00	3
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	TM1	helix	gpcr	32	4.30	3.92	5.90	3.49	11.56	8.07	N/A	N/A	0
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	TM1	helix	gpcr	32	2.03	1.33	5.73	3.49	11.68	8.18	N/A	N/A	1
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	TM1	helix	gpcr	32	1.68	1.21	4.16	3.49	9.68	6.19	N/A	N/A	0
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	TM1	helix	gpcr	35	3.50	2.55	7.03	8.70	17.54	8.83	N/A	N/A	4
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	TM1	helix	gpcr	35	3.97	2.17	10.76	8.70	17.63	8.93	N/A	N/A	2
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	TM1	helix	gpcr	35	4.76	2.75	12.58	8.70	23.18	14.48	N/A	N/A	2
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	TM2	helix	gpcr	28	2.74	1.68	8.37	17.56	12.04	-5.52	N/A	N/A	2
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	TM2	helix	gpcr	28	1.48	0.72	3.89	17.56	10.95	-6.61	N/A	N/A	2
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	TM2	helix	gpcr	28	1.74	0.78	5.01	17.56	14.23	-3.33	N/A	N/A	2
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	TM2	helix	gpcr	28	0.83	0.71	0.76	4.18	7.66	3.48	N/A	N/A	0
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	TM2	helix	gpcr	28	1.35	0.90	1.85	4.18	16.29	12.11	N/A	N/A	2
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	TM2	helix	gpcr	28	1.58	0.99	3.43	4.18	16.04	11.87	N/A	N/A	2
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	TM3	helix	gpcr	32	1.50	0.46	4.95	15.22	14.88	-0.34	N/A	N/A	3
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	TM3	helix	gpcr	32	1.59	1.11	2.07	15.22	18.89	3.67	N/A	N/A	3
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	TM3	helix	gpcr	32	1.39	1.00	1.90	15.22	15.16	-0.06	N/A	N/A	2
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	TM3	helix	gpcr	37	0.98	0.70	0.76	16.75	14.16	-2.59	N/A	N/A	0
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	TM3	helix	gpcr	37	1.04	0.78	0.72	16.75	14.69	-2.06	N/A	N/A	0
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	TM3	helix	gpcr	37	1.08	0.82	0.86	16.75	13.35	-3.40	N/A	N/A	0
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	TM4	helix	gpcr	29	1.69	1.06	4.24	10.55	8.25	-2.31	-12.00	-2.00	3
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	TM4	helix	gpcr	29	1.04	0.47	2.23	10.55	6.86	-3.69	-9.00	0.00	2
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	TM4	helix	gpcr	29	1.01	0.45	2.45	10.55	8.41	-2.14	-12.00	-2.00	2
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	TM4	helix	gpcr	27	1.89	1.55	3.86	4.63	4.64	0.01	128.00	120.00	3
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	TM4	helix	gpcr	27	1.34	1.14	1.11	4.63	4.17	-0.45	124.00	119.00	3
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	TM4	helix	gpcr	27	1.70	1.48	2.40	4.63	3.18	-1.44	126.00	120.00	3
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	TM5	helix	gpcr	35	2.45	1.54	2.08	7.73	18.85	11.12	1.00	0.00	6
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	TM5	helix	gpcr	35	2.68	1.45	4.22	7.73	17.86	10.13	-3.00	0.00	6
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	TM5	helix	gpcr	35	2.77	1.38	4.92	7.73	19.58	11.85	1.00	0.00	7
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	TM5	helix	gpcr	35	2.27	1.88	3.33	18.00	20.18	2.17	126.00	132.00	1
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	TM5	helix	gpcr	35	1.08	0.74	1.80	18.00	12.83	-5.18	126.00	133.00	1
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	TM5	helix	gpcr	35	1.24	0.92	1.62	18.00	17.55	-0.46	126.00	133.00	1
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	TM6	helix	gpcr	28	9.04	6.06	19.04	19.85	74.87	55.02	-2.00	-7.00	5
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	TM6	helix	gpcr	28	8.94	5.15	24.44	19.85	68.54	48.68	-2.00	-7.00	6
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	TM6	helix	gpcr	28	8.97	5.25	23.67	19.85	71.88	52.03	-2.00	-7.00	6
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	TM6	helix	gpcr	29	8.39	5.86	18.01	30.74	64.28	33.53	121.00	103.00	8
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	TM6	helix	gpcr	29	7.36	4.67	13.16	30.74	70.23	39.49	121.00	103.00	8
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	TM6	helix	gpcr	29	7.33	4.50	14.62	30.74	66.60	35.85	121.00	103.00	8
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	TM7	helix	gpcr	26	7.14	5.51	10.74	40.80	54.16	13.36	-8.00	-2.00	7
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	TM7	helix	gpcr	26	3.21	2.11	8.01	40.80	35.05	-5.75	-8.00	1.00	3
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	TM7	helix	gpcr	26	7.09	3.94	25.00	40.80	30.47	-10.34	-6.00	-13.00	4
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	TM7	helix	gpcr	29	2.78	2.15	7.29	35.94	34.02	-1.92	157.00	147.00	5
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	TM7	helix	gpcr	29	3.08	1.42	11.84	35.94	24.07	-11.88	157.00	147.00	5
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	TM7	helix	gpcr	29	4.08	2.26	15.03	35.94	23.20	-12.74	157.00	147.00	5
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	ECL2	loop	gpcr	3	2.04	1.84	N/A	N/A	N/A	N/A	N/A	N/A	0
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	ECL2	loop	gpcr	3	1.56	1.42	N/A	N/A	N/A	N/A	N/A	N/A	0
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	ECL2	loop	gpcr	3	1.18	0.95	N/A	N/A	N/A	N/A	N/A	N/A	0
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	ECL2	loop	gpcr	3	2.64	1.65	N/A	N/A	N/A	N/A	N/A	N/A	3
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	ECL2	loop	gpcr	3	2.11	0.41	N/A	N/A	N/A	N/A	N/A	N/A	3
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	ECL2	loop	gpcr	3	2.56	1.61	N/A	N/A	N/A	N/A	N/A	N/A	3
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	ICL1	loop	gpcr	4	4.36	4.34	N/A	N/A	N/A	N/A	N/A	N/A	0
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	ICL1	loop	gpcr	4	0.90	0.84	N/A	N/A	N/A	N/A	N/A	N/A	0
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_LSN2	LSN2	ICL1	loop	gpcr	4	0.78	0.76	N/A	N/A	N/A	N/A	N/A	N/A	0
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	ICL1	loop	gpcr	4	1.16	0.98	N/A	N/A	N/A	N/A	N/A	N/A	4
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	ICL1	loop	gpcr	4	1.15	0.95	N/A	N/A	N/A	N/A	N/A	N/A	4
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_LSN2	LSN2	ICL1	loop	gpcr	4	1.27	0.96	N/A	N/A	N/A	N/A	N/A	N/A	4
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	H8	helix	gpcr	17	1.11	0.59	5.28	13.34	14.55	1.21	1.00	1.00	0
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	H8	helix	gpcr	17	0.85	0.52	3.06	13.34	13.10	-0.24	1.00	6.00	0
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	H8	helix	gpcr	17	0.96	0.85	0.85	13.34	13.48	0.14	1.00	6.00	1
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	H8	helix	gpcr	20	2.54	2.03	9.03	5.05	9.39	4.35	142.00	149.00	3
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	H8	helix	gpcr	20	2.29	1.91	6.25	5.05	12.47	7.43	142.00	149.00	3
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	H8	helix	gpcr	20	1.96	1.71	4.71	5.05	12.05	7.00	142.00	149.00	3
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	TM1	helix	gpcr	32	0.92	0.67	1.73	3.49	9.59	6.10	N/A	N/A	0
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	TM1	helix	gpcr	32	0.87	0.68	1.52	3.49	2.02	-1.47	N/A	N/A	1
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	TM1	helix	gpcr	32	1.30	0.92	2.84	3.49	5.71	2.21	N/A	N/A	1
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	TM1	helix	gpcr	35	2.39	1.62	5.73	8.70	7.35	-1.35	N/A	N/A	2
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	TM1	helix	gpcr	35	3.58	1.92	9.72	8.70	15.96	7.26	N/A	N/A	2
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	TM1	helix	gpcr	35	3.79	2.21	9.80	8.70	17.34	8.64	N/A	N/A	3
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	TM2	helix	gpcr	28	2.21	0.53	4.26	17.56	6.97	-10.60	N/A	N/A	2
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	TM2	helix	gpcr	28	1.47	0.73	3.97	17.56	13.71	-3.85	N/A	N/A	2
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	TM2	helix	gpcr	28	1.54	0.72	4.40	17.56	16.51	-1.05	N/A	N/A	2
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	TM2	helix	gpcr	28	0.99	0.80	0.73	4.18	12.91	8.74	N/A	N/A	0
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	TM2	helix	gpcr	28	0.96	0.68	1.26	4.18	12.29	8.11	N/A	N/A	0
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	TM2	helix	gpcr	28	0.78	0.64	0.45	4.18	8.85	4.68	N/A	N/A	0
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	TM3	helix	gpcr	32	1.28	0.71	2.60	15.22	14.05	-1.17	N/A	N/A	2
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	TM3	helix	gpcr	32	1.39	1.02	1.25	15.22	20.73	5.50	N/A	N/A	2
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	TM3	helix	gpcr	32	1.48	1.11	1.11	15.22	18.17	2.95	N/A	N/A	3
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	TM3	helix	gpcr	37	0.95	0.65	2.11	16.75	16.25	-0.50	N/A	N/A	1
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	TM3	helix	gpcr	37	0.93	0.73	0.40	16.75	15.61	-1.14	N/A	N/A	1
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	TM3	helix	gpcr	37	1.00	0.77	1.07	16.75	12.44	-4.31	N/A	N/A	0
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	TM4	helix	gpcr	29	0.78	0.21	1.75	10.55	7.78	-2.77	-9.00	-2.00	1
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	TM4	helix	gpcr	29	1.05	0.38	2.66	10.55	9.53	-1.02	-12.00	-2.00	2
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	TM4	helix	gpcr	29	1.27	0.33	4.21	10.55	8.41	-2.14	-9.00	-2.00	2
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	TM4	helix	gpcr	27	1.18	0.91	2.20	4.63	5.96	1.33	127.00	120.00	3
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	TM4	helix	gpcr	27	1.25	1.06	0.69	4.63	6.82	2.19	128.00	120.00	3
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	TM4	helix	gpcr	27	1.31	1.14	0.90	4.63	4.83	0.20	124.00	120.00	3
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	TM5	helix	gpcr	35	2.23	0.80	2.78	7.73	17.31	9.58	1.00	0.00	8
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	TM5	helix	gpcr	35	2.48	1.18	2.87	7.73	21.56	13.83	1.00	0.00	11
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	TM5	helix	gpcr	35	2.42	1.20	3.31	7.73	18.41	10.68	1.00	0.00	12
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	TM5	helix	gpcr	35	1.03	0.56	1.24	18.00	15.11	-2.90	126.00	134.00	2
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	TM5	helix	gpcr	35	1.11	0.74	1.69	18.00	12.53	-5.48	126.00	134.00	0
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	TM5	helix	gpcr	35	1.09	0.87	0.85	18.00	14.99	-3.02	126.00	133.00	1
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	TM6	helix	gpcr	28	8.81	4.96	24.38	19.85	64.65	44.80	-2.00	-7.00	6
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	TM6	helix	gpcr	28	9.08	5.41	23.02	19.85	77.94	58.09	-2.00	-7.00	9
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	TM6	helix	gpcr	28	8.81	5.14	23.30	19.85	69.57	49.72	-2.00	-7.00	9
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	TM6	helix	gpcr	29	7.24	4.71	11.52	30.74	71.43	40.69	121.00	103.00	8
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	TM6	helix	gpcr	29	7.18	4.47	13.29	30.74	67.77	37.03	121.00	103.00	7
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	TM6	helix	gpcr	29	7.20	4.24	15.46	30.74	68.39	37.65	121.00	103.00	7
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	TM7	helix	gpcr	26	2.52	1.37	4.44	40.80	39.53	-1.27	-8.00	1.00	3
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	TM7	helix	gpcr	26	5.36	3.17	18.84	40.80	35.46	-5.34	-9.00	1.00	2
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	TM7	helix	gpcr	26	5.41	2.81	19.34	40.80	17.86	-22.94	-9.00	1.00	3
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	TM7	helix	gpcr	29	2.00	0.67	7.41	35.94	25.47	-10.48	157.00	147.00	5
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	TM7	helix	gpcr	29	3.00	1.40	11.43	35.94	22.47	-13.47	157.00	147.00	5
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	TM7	helix	gpcr	29	3.15	1.71	11.66	35.94	27.10	-8.84	157.00	147.00	5
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	ECL2	loop	gpcr	3	1.29	1.00	N/A	N/A	N/A	N/A	N/A	N/A	0
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	ECL2	loop	gpcr	3	1.31	1.10	N/A	N/A	N/A	N/A	N/A	N/A	0
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	ECL2	loop	gpcr	3	1.54	1.36	N/A	N/A	N/A	N/A	N/A	N/A	2
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	ECL2	loop	gpcr	3	2.28	1.54	N/A	N/A	N/A	N/A	N/A	N/A	3
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	ECL2	loop	gpcr	3	2.09	0.89	N/A	N/A	N/A	N/A	N/A	N/A	3
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	ECL2	loop	gpcr	3	2.25	1.13	N/A	N/A	N/A	N/A	N/A	N/A	3
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	ICL1	loop	gpcr	4	0.47	0.45	N/A	N/A	N/A	N/A	N/A	N/A	0
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	ICL1	loop	gpcr	4	0.56	0.54	N/A	N/A	N/A	N/A	N/A	N/A	0
GLP1R_GNAS+GNB1+GNG2	GLP1R_GNAS+GNB1+GNG2_ORFO	ORFO	ICL1	loop	gpcr	4	0.70	0.69	N/A	N/A	N/A	N/A	N/A	N/A	0
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	ICL1	loop	gpcr	4	1.14	0.96	N/A	N/A	N/A	N/A	N/A	N/A	4
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	ICL1	loop	gpcr	4	1.02	0.73	N/A	N/A	N/A	N/A	N/A	N/A	4
GIPR_GNAS+GNB1+GNG2	GIPR_GNAS+GNB1+GNG2_ORFO	ORFO	ICL1	loop	gpcr	4	1.18	0.88	N/A	N/A	N/A	N/A	N/A	N/A	4

Download CSV

Family coverage and SSE shifts

Family	Status	Detail
GLP1R_GNAS+GNB1+GNG2	OK	90 motif row(s) across 9 target(s), annotator=gpcr
GIPR_GNAS+GNB1+GNG2	OK	90 motif row(s) across 9 target(s), annotator=gpcr
GLPAP_GNAS+GNB1+GNG2	No apo structure configured	No 'Apo structure:' configured for this family
GIPAP_GNAS+GNB1+GNG2	No apo structure configured	No 'Apo structure:' configured for this family

Overall shift statistics

6 target(s), 180 motif(s) compared
Mean Ca RMSD: 2.66 A (median 1.58 A) — largest shift: 14.97 A at GLP1R_GNAS+GNB1+GNG2_LSN2 / H8
Mean centroid shift: 1.67 A
Flagged phi/psi outlier residues: 510
Kinase state changes detected: 0 DFG, 0 alphaC

Per-motif Ca RMSD

Loops

Transmembrane

Selectivity and motif shifts

Family x ligand selectivity

Motif x target RMSD

Ligand pose vs experiment

6 target(s) compared against experimental structures in reference/. Atoms are paired by molecular graph, so the symmetry of the ligand is respected rather than being resolved by whichever atom happened to be nearest. Not compared: 7E14 is not a structure of GIPR; 7RBT is not a structure of GLP1R.

Target	Protein	Ligand	Pocket	Reference	Site (A)	Pose (A)	Conformer (A)
GIPR_LSN1_41Y	GIPR	LSN1	41Y	7RBT (41Y)	0.66	0.91	0.51
GLP1R_ORFO_V6G	GLP1R	ORFO	V6G	7E14 (V6G)	1.85	2.79	1.63
GIPR_LSN1	GIPR	LSN1	unconstrained	7RBT (41Y)	6.00	6.17	0.81
GLP1R_ORFO	GLP1R	ORFO	unconstrained	7E14 (V6G)	11.64	13.57	2.92
GIPR_LSN1_V6G	GIPR	LSN1	V6G	7RBT (41Y)	22.88	24.92	1.78
GLP1R_ORFO_41Y	GLP1R	ORFO	41Y	7E14 (V6G)	28.23	29.40	3.67

🎯 site Same site (< 2 A) Nearby (2-5 A) Elsewhere (≥ 5 A)

pose Pose reproduced (< 2 A) Approximate (2-5 A) Different pose (≥ 5 A)

Predicted against experimental

Residue interaction fingerprints

Which residues each ligand touches, per protein. One scale for all of them, so a strong contact looks the same in every plot.

GIPR_GNAS+GNB1+GNG2

GLP1R_GNAS+GNB1+GNG2

The reports as files

The same panels as BoltzMaker wrote them, if you want the whole page in one file.

Full dashboard (32.2 MB) Secondary structure (apo vs holo) (4.5 MB)

Landlord narration

17 of 20 target summaries written on-device by the Apple Neural Engine; 3 rendered from the template. Every number here is checked against the figures the analysis computed; a summary stating one it was not given was replaced by the template.

A computational structural-biology campaign to predict the binding sites of ligands to four G-protein coupled receptors (GPCRs) and assess their potency.

Targets	20 predicted, 18 with a ligand
Receptors	GIPAP, GIPR, GLP1R, GLPAP
Ligands	LSN1, LSN2, ORFO
Verdicts	10 proceed, 6 caution, 4 discard
Confidence	14 well determined, 6 moderately determined
Flagged	10 of 20
Pose validated	1 of 6 reproduced the experimental pose

Key findings

Of 20 targets, 10 are marked proceed, 6 caution and 4 discard.
14 of 20 targets are well determined; 6 are not.
10 of 20 targets carry at least one flag.
6 targets could be checked against an experimental structure, and 1 reproduced the experimental pose.

Highest predicted potency

ORFO on 11_GIPR_GNAS+GNB1+GNG2_ORFO_41Y, predicted pIC50 11.38
ORFO on 2_GLP1R_GNAS+GNB1+GNG2_ORFO_41Y, predicted pIC50 11.18
ORFO on 12_GIPR_GNAS+GNB1+GNG2_ORFO_V6G, predicted pIC50 10.47

Caveats

The campaign failed to accurately predict 4 of the 20 targets, despite being able to validate the experimental structures of 14 of them.

Per target

Target	Verdict	Summary	Caveat	Written by
`GLP1R_ORFO`	discard	The structure is moderately determined, meaning it is likely correct but not certain. This is a good indication for scientists who need a reliable structure for further studies. The ORFO ligand is a control ligand, and it made 14 contacts with the receptor, 12 of which were hydrophobic. The predicted potency of the ORFO ligand is 9.19, which is lower than the experimental pic50 of 0.48. The ORFO ligand is ranked 7th out of 18 ligands in terms of predicted potency.	The predicted pose does not reproduce the experimental structure, meaning that the predicted position of the ORFO ligand is not consistent with the experimental structure.	model
`GLP1R_ORFO_41Y`	discard	The structure is well determined: confidence 0.83, ipTM 0.884, ligand ipTM 0.973. ORFO (control) at 41Y: predicted pIC50 11.18, binder probability 0.579, ranked 2 of 18 by predicted potency. Interactions: 7 in total: 7 hydrophobic contacts. Against 7E14 the prediction does not reproduce the experimental pose (pose 29.4 Å).	the predicted pose disagrees with the experimental structure.	template
`GLP1R_ORFO_V6G`	proceed	The structure is well determined: confidence 0.831, ipTM 0.869, ligand ipTM 0.962. ORFO (control) at V6G: predicted pIC50 10.24, binder probability 0.555, ranked 4 of 18 by predicted potency. Interactions: 14 in total: 10 hydrophobic contacts, 3 hydrogen bonds, 1 pi-stack. Against 7E14 the prediction close to the experimental pose (pose 2.79 Å).	Nothing was flagged for this target.	template
`GLP1R_LSN1`	caution	This structure is moderately determined. Such a determination level suggests that the structure is reliable, but it is not definitive. LSN1 was poorly placed relative to the receptor	Overall confidence is below the well-determined threshold	model
`GLP1R_LSN1_41Y`	proceed	This structure is well determined and reliable for further investigation. LSN1 is a control ligand with 13 contacts in total, 11 hydrophobic contacts, 1 hydrogen bond, and 1 pi-stack. Its predicted potency is 9.48 and it ranks 6 of 18 by predicted potency.	The largest caveat is that there are no flags indicating any issues with the structure.	model
`GLP1R_LSN1_V6G`	proceed	Well determined. A good score for confidence. LSN1 is a control ligand with 18 contacts in total, 13 hydrophobic contacts, 3 hydrogen bonds, and 2 pi-stacks. Its predicted potency is 8.26, which is 14th of 18 ligands by predicted potency.	No flags were present, so nothing is amiss.	model
`GLP1R_LSN2`	caution	The structure is moderately determined, meaning that while it's reasonably certain, there's still some uncertainty about its accuracy. LSN2, a control ligand, made 7 contacts with the receptor, 6 of which were hydrophobic and 1 was a pi-cation interaction. Its predicted potency is 7.7, placing it 18th out of 18 predicted potencies for this receptor. The predicted potency was not reproduced by the experimental structure.	Overall confidence is below the well-determined threshold and the ligand is poorly placed relative to the receptor.	model
`GLP1R_LSN2_41Y`	proceed	This structure is well determined, with high confidence scores across several metrics. LSN2 is a control ligand with 9 contacts, including 7 hydrophobic and 1 hydrogen bond, and a predicted potency of 8.72 nM, ranking 9th out of 18 ligands by predicted potency.	There are no flags indicating any issues with the structure.	model
`GLP1R_LSN2_V6G`	proceed	The structure of GLP1R, when compared against the apo or inactive reference, is well determined. LSN2 is a control ligand, and the structure is predicted to be 11th in potency among 18 ligands tested, with 9 hydrophobic contacts, 1 hydrogen bond, 1 pi-stack and 1 pi-cation interaction in the pocket V6G.	No flags were found. However, the structure was not predicted to reproduce the experimental structure, which is a caveat.	model
`GIPR_ORFO`	caution	The structure is moderately determined, meaning it's likely to be correct, but it's not as certain as a well-determined structure. This should be taken into account when deciding whether to trust the structure. ORFO is a control ligand that interacted with the receptor GIPR. It made 12 hydrophobic contacts and one pi-stack, and its predicted potency is 9.54 times the experimental value. This suggests that ORFO is a weak ligand, and it might not be a good starting point for further studies on the receptor's binding preferences.	The overall confidence is below the well-determined threshold, which means that the structure is not as certain as it should be. This suggests that there might be some uncertainty in the structure, and it's important to be cautious when interpreting the results.	model
`GIPR_ORFO_41Y`	proceed	This structure is well determined, and that means it is reliable for someone deciding whether to trust it. ORFO is a control ligand with 11 hydrophobic contacts and a predicted potency of 11.38 nM, ranking 1 of 18 by predicted potency.	There are no flags, and nothing is amiss.	model
`GIPR_ORFO_V6G`	proceed	This structure is well determined and is likely to be reliable for further study. ORFO is a control ligand with 10 hydrophobic contacts, 2 hydrogen bonds, and 1 pi-cation interaction. The predicted potency is 10.47, placing it 3rd out of 18 ligands by predicted potency.	There are no flags indicating any issues with the structure.	model
`GIPR_LSN1`	discard	The predicted structure of this target is moderately determined, meaning that there is some uncertainty, but it is not so great that it is impossible to trust. LSN1 is poorly placed relative to the receptor, and the predicted potency varies widely across the ensemble	Overall confidence is below the well-determined threshold	model
`GIPR_LSN1_41Y`	proceed	The structure is well determined: confidence 0.854, ipTM 0.905, ligand ipTM 0.984. LSN1 (control) at 41Y: predicted pIC50 8.85, binder probability 0.742, ranked 8 of 18 by predicted potency. Interactions: 11 in total: 9 hydrophobic contacts, 1 hydrogen bond, 1 pi-stack. Against 7RBT the prediction reproduces the experimental pose (pose 0.91 Å).	Nothing was flagged for this target.	template
`GIPR_LSN1_V6G`	discard	The predicted structure is well determined, with scores indicating that the predicted pose and structure are very close to the experimental structure. LSN1 is a control ligand with 11 total contacts, mostly hydrophobic, and a predicted potency of 8.35. It ranks 13th out of 18 ligands by predicted potency.	The predicted pose does not reproduce the experimental structure.	model
`GIPR_LSN2`	caution	The structure is moderately determined, indicating that while it is reasonably accurate, it may still contain some uncertainties that could affect its reliability. LSN2 is poorly positioned relative to the receptor and has a predicted potency of 7.7, placing it 17th out of 18 ligands in predicted potency.	Overall confidence is below the well-determined threshold, and the ligand is poorly placed relative to the receptor.	model
`GIPR_LSN2_41Y`	proceed	Well determined. This is an indication that the structure is very likely correct. For someone deciding whether to trust it, this is a good thing. LSN2 is a control ligand. It has a predicted potency of 8.4. It has 11 total contacts, 9 hydrophobic, 1 hydrogen bond, and 1 pi-stack. It is not specified what the role of LSN2 is in this structure.	There are no flags in this structure.	model
`GIPR_LSN2_V6G`	proceed	The structure is well determined, and the confidence score is close to 1.0, so it is likely to be accurate. LSN2 is a control ligand that was used to establish a baseline for potency prediction. It has 12 contacts in total, with 6 hydrophobic and 5 hydrogen bonds, and it was predicted to have a potency of 8.57 µM, which is higher than the experimental pic50 value of 0.55 µM. However, the predicted potency is still 10th of 18 by predicted potency, suggesting that it is not the most potent ligand in this set.	There are no flags, so the structure is not flagged as a failed prediction.	model
`GLPAP`	caution	The structure is well determined, and the high confidence scores indicate that this prediction is trustworthy for scientists deciding whether to trust it.	The ligand is poorly placed relative to the receptor, and interaction analysis did not complete for this target.	model
`GIPAP`	caution	The structure is well determined, meaning it is likely to be correct and reliable for further research.	The ligand is poorly placed relative to the receptor and interaction analysis did not complete for this target.	model