Family coverage
| Family | Status | Detail |
|---|---|---|
| ADRB2_GNAS | OK | 14 motif row(s) across 1 target(s), annotator=gpcr |
| ADRB2 | OK | 14 motif row(s) across 1 target(s), annotator=gpcr |
Overall shift statistics
- 2 target(s), 28 motif(s) compared
- Mean Ca RMSD: 3.49 A (median 0.95 A) — largest shift: 33.07 A at ADRB2_GNAS_ISO1 / ECL3
- Mean centroid shift: 2.98 A
- Flagged phi/psi outlier residues: 30
- Kinase state changes detected: 0 DFG, 0 alphaC
SSE motif shifts (apo vs holo)
| Identity | Shift | Helix geometry | Backbone | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Family | Target | Ligand | Motif | Kind | Source | N res | RMSD (A) | Centroid delta (A) | Axis rot (deg) | Kink apo (deg) | Kink holo (deg) | Kink delta (deg) | Flagged phi/psi |
| ADRB2_GNAS | ADRB2_GNAS_ISO1 | ISO1 | H8 | helix | gpcr | 13 | 1.69 | 1.43 | 8.22 | 25.89 | 20.90 | -4.99 | 1 |
| ADRB2_GNAS | ADRB2_GNAS_ISO1 | ISO1 | TM1 | helix | gpcr | 33 | 1.74 | 0.89 | 4.47 | 6.12 | 12.55 | 6.43 | 0 |
| ADRB2_GNAS | ADRB2_GNAS_ISO1 | ISO1 | TM2 | helix | gpcr | 31 | 0.70 | 0.41 | 2.06 | 20.09 | 17.08 | -3.01 | 0 |
| ADRB2_GNAS | ADRB2_GNAS_ISO1 | ISO1 | TM3 | helix | gpcr | 36 | 1.03 | 0.71 | 1.98 | 15.02 | 11.97 | -3.06 | 2 |
| ADRB2_GNAS | ADRB2_GNAS_ISO1 | ISO1 | TM4 | helix | gpcr | 27 | 1.00 | 0.57 | 2.87 | 10.96 | 17.92 | 6.96 | 0 |
| ADRB2_GNAS | ADRB2_GNAS_ISO1 | ISO1 | TM5 | helix | gpcr | 34 | 1.52 | 0.92 | 3.58 | 9.31 | 11.79 | 2.48 | 1 |
| ADRB2_GNAS | ADRB2_GNAS_ISO1 | ISO1 | TM6 | helix | gpcr | 37 | 5.84 | 3.28 | 14.39 | 31.68 | 27.14 | -4.55 | 3 |
| ADRB2_GNAS | ADRB2_GNAS_ISO1 | ISO1 | TM7 | helix | gpcr | 25 | 2.17 | 1.46 | 4.68 | 28.61 | 17.87 | -10.74 | 3 |
| ADRB2_GNAS | ADRB2_GNAS_ISO1 | ISO1 | ECL1 | loop | gpcr | 4 | 0.56 | 0.37 | N/A | N/A | N/A | N/A | 0 |
| ADRB2_GNAS | ADRB2_GNAS_ISO1 | ISO1 | ECL2 | loop | gpcr | 3 | 0.58 | 0.52 | N/A | N/A | N/A | N/A | 0 |
| ADRB2_GNAS | ADRB2_GNAS_ISO1 | ISO1 | ECL3 | loop | gpcr | 1 | 33.07 | 33.07 | N/A | N/A | N/A | N/A | 1 |
| ADRB2_GNAS | ADRB2_GNAS_ISO1 | ISO1 | H8loop | loop | gpcr | 2 | 1.48 | 0.71 | N/A | N/A | N/A | N/A | 0 |
| ADRB2_GNAS | ADRB2_GNAS_ISO1 | ISO1 | ICL1 | loop | gpcr | 4 | 1.73 | 1.72 | N/A | N/A | N/A | N/A | 0 |
| ADRB2_GNAS | ADRB2_GNAS_ISO1 | ISO1 | ICL2 | loop | gpcr | 8 | 5.24 | 3.48 | N/A | N/A | N/A | N/A | 6 |
| ADRB2 | ADRB2_PRO1 | PRO1 | H8 | helix | gpcr | 13 | 0.50 | 0.42 | 1.89 | 25.89 | 25.29 | -0.59 | 0 |
| ADRB2 | ADRB2_PRO1 | PRO1 | TM1 | helix | gpcr | 33 | 0.58 | 0.08 | 0.87 | 6.12 | 8.13 | 2.01 | 0 |
| ADRB2 | ADRB2_PRO1 | PRO1 | TM2 | helix | gpcr | 31 | 0.25 | 0.08 | 0.25 | 20.09 | 17.40 | -2.69 | 0 |
| ADRB2 | ADRB2_PRO1 | PRO1 | TM3 | helix | gpcr | 36 | 0.53 | 0.21 | 1.41 | 15.02 | 15.02 | 0.00 | 1 |
| ADRB2 | ADRB2_PRO1 | PRO1 | TM4 | helix | gpcr | 27 | 0.41 | 0.32 | 0.68 | 10.96 | 11.48 | 0.52 | 0 |
| ADRB2 | ADRB2_PRO1 | PRO1 | TM5 | helix | gpcr | 34 | 0.69 | 0.56 | 0.84 | 9.31 | 9.52 | 0.22 | 1 |
| ADRB2 | ADRB2_PRO1 | PRO1 | TM6 | helix | gpcr | 37 | 3.06 | 1.13 | 3.32 | 31.68 | 28.93 | -2.75 | 4 |
| ADRB2 | ADRB2_PRO1 | PRO1 | TM7 | helix | gpcr | 25 | 0.50 | 0.16 | 1.10 | 28.61 | 24.03 | -4.59 | 0 |
| ADRB2 | ADRB2_PRO1 | PRO1 | ECL1 | loop | gpcr | 4 | 0.49 | 0.36 | N/A | N/A | N/A | N/A | 0 |
| ADRB2 | ADRB2_PRO1 | PRO1 | ECL2 | loop | gpcr | 3 | 0.60 | 0.53 | N/A | N/A | N/A | N/A | 0 |
| ADRB2 | ADRB2_PRO1 | PRO1 | ECL3 | loop | gpcr | 1 | 24.76 | 24.76 | N/A | N/A | N/A | N/A | 1 |
| ADRB2 | ADRB2_PRO1 | PRO1 | H8loop | loop | gpcr | 2 | 0.91 | 0.56 | N/A | N/A | N/A | N/A | 0 |
| ADRB2 | ADRB2_PRO1 | PRO1 | ICL1 | loop | gpcr | 4 | 0.58 | 0.54 | N/A | N/A | N/A | N/A | 0 |
| ADRB2 | ADRB2_PRO1 | PRO1 | ICL2 | loop | gpcr | 8 | 5.60 | 4.11 | N/A | N/A | N/A | N/A | 6 |